---
title: "ICD-10-CM Z79.818: Long term (current) use of other agents… | BillingBrief"
description: "ICD-10-CM code Z79.818: Long term (current) use of other agents affecting estrogen receptors and estrogen levels. Category, related codes, and the official…"
canonical: "https://billingbrief.com/icd10/z79.818/"
language: "en"
---

# Z79.818 Long term (current) use of other agents affecting estrogen receptors and estrogen levels

ICD-10-CM · [CMS code reference](#source)

**Official ICD-10-CM description:** Long term (current) use of other agents affecting estrogen receptors and estrogen levels

## Coding notes

From the ICD-10-CM FY2027 (effective October 1, 2026) tabular list. Notes on a parent code or category apply here too.

### Also covers

-   Long term (current) use of estrogen receptor downregulators
-   Long term (current) use of fulvestrant (Faslodex)
-   Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
-   Long term (current) use of goserelin acetate (Zoladex)
-   Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
-   Long term (current) use of megestrol acetate (Megace)

### Includes

-   long term (current) drug use for prophylactic purposes

### Excludes1

Not coded together with this code. The exception is when the two conditions are unrelated to each other.

-   hormone replacement therapy ([Z79.890](https://billingbrief.com/icd10/z79.890/))

### Excludes2

Not part of this code, but both can be coded when both are documented.

-   drug abuse and dependence (F11-F19)
-   drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

### Code first

Code the underlying condition first, then this code.

-   , if applicable:
-   malignant neoplasm of breast (C50.-)
-   malignant neoplasm of prostate (C61)

### Use additional code

Add a second code for the following, when documented.

-   code, if applicable, to identify:
-   estrogen receptor positive status (Z17.0)
-   family history of breast cancer (Z80.3)
-   genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)
-   personal history of breast cancer (Z85.3)
-   personal history of prostate cancer (Z85.46)
-   postmenopausal status (Z78.0)

### Code also

A second code may be needed. Sequencing depends on the encounter.

-   any therapeutic drug level monitoring ([Z51.81](https://billingbrief.com/icd10/z51.81/))
-   any follow-up examination (Z08-[Z09](https://billingbrief.com/icd10/z09/))

## Related codes

-   [`Z79.810` Long term (current) use of selective estrogen receptor modulators (SERMs) ICD-10-CM](https://billingbrief.com/icd10/z79.810/)
-   [`Z79.811` Long term (current) use of aromatase inhibitors ICD-10-CM](https://billingbrief.com/icd10/z79.811/)
-   [`Z79.82` Long term (current) use of aspirin ICD-10-CM](https://billingbrief.com/icd10/z79.82/)
-   [`Z79.83` Long term (current) use of bisphosphonates ICD-10-CM](https://billingbrief.com/icd10/z79.83/)
-   [`Z79.84` Long term (current) use of oral hypoglycemic drugs ICD-10-CM](https://billingbrief.com/icd10/z79.84/)
-   [`Z79.85` Long-term (current) use of injectable non-insulin antidiabetic drugs ICD-10-CM](https://billingbrief.com/icd10/z79.85/)
-   [`Z79.890` Hormone replacement therapy ICD-10-CM](https://billingbrief.com/icd10/z79.890/)
-   [`Z79.891` Long term (current) use of opiate analgesic ICD-10-CM](https://billingbrief.com/icd10/z79.891/)

## Common questions

### Is Z79.818 a billable code?

Yes. Z79.818 is a billable ICD-10-CM code in the ICD-10-CM FY2027 (effective October 1, 2026) code set.

## From the source

Official description from [CMS](https://www.cms.gov/medicare/coding-billing/icd-10-codes).
ICD-10-CM FY2027 (effective October 1, 2026).

Code set

ICD-10-CM

Category

Z79 Long term (current) drug therapy

Chapter

Factors influencing health status and contact with health services

Billable

Yes

Educational reference only. Not medical, legal, or billing advice. Always check the current official code set and payer policy before you bill. [About BillingBrief and our sources](https://billingbrief.com/about/).