---
title: "ICD-10-CM F43.21: Adjustment disorder with depressed mood | BillingBrief"
description: "ICD-10-CM code F43.21: Adjustment disorder with depressed mood. Category, related codes, and the official source, in plain English."
canonical: "https://billingbrief.com/icd10/f43.21/"
language: "en"
---

# F43.21 Adjustment disorder with depressed mood

ICD-10-CM · [CMS code reference](#source)

**Official ICD-10-CM description:** Adjustment disorder with depressed mood

## Related codes

-   [`F43.0` Acute stress reaction ICD-10-CM](https://billingbrief.com/icd10/f43.0/)
-   [`F43.10` Post-traumatic stress disorder, unspecified ICD-10-CM](https://billingbrief.com/icd10/f43.10/)
-   [`F43.11` Post-traumatic stress disorder, acute ICD-10-CM](https://billingbrief.com/icd10/f43.11/)
-   [`F43.12` Post-traumatic stress disorder, chronic ICD-10-CM](https://billingbrief.com/icd10/f43.12/)
-   [`F43.20` Adjustment disorder, unspecified ICD-10-CM](https://billingbrief.com/icd10/f43.20/)
-   [`F43.22` Adjustment disorder with anxiety ICD-10-CM](https://billingbrief.com/icd10/f43.22/)
-   [`F43.23` Adjustment disorder with mixed anxiety and depressed mood ICD-10-CM](https://billingbrief.com/icd10/f43.23/)
-   [`F43.24` Adjustment disorder with disturbance of conduct ICD-10-CM](https://billingbrief.com/icd10/f43.24/)

## Common questions

### Is F43.21 a billable code?

Yes. F43.21 is a billable ICD-10-CM code in the ICD-10-CM FY2027 (effective October 1, 2026) code set.

## From the source

Official description from [CMS](https://www.cms.gov/medicare/coding-billing/icd-10-codes).
ICD-10-CM FY2027 (effective October 1, 2026).

Code set

ICD-10-CM

Category

F43 Reaction to severe stress, and adjustment disorders

Chapter

Mental, behavioral and neurodevelopmental disorders

Billable

Yes

Educational reference only. Not medical, legal, or billing advice. Always check the current official code set and payer policy before you bill. [About BillingBrief and our sources](https://billingbrief.com/about/).